Know All About the New Treatments for Lymphoma and Leukemia Cancer

Blood cancer or Hematologic cancer develops when abnormal cells grow without control in the bone marrow. The production of normal cells gets hindered, and the body is unable to fight off infections. There are mainly three types of blood cancers: Leukemia, Lymphoma (Non-Hodgkin and Hodgkin), and Myeloma.

Blood cancer affects hundreds of thousands of people belonging to various age groups. New treatments for blood cancer have been able to improve the survival rate over the past few decades. However, the fight against this cancer is never-ending, and new advances in research are crucial. 

Some of the new treatments for leukaemia and lymphoma are CAR-T cell immunotherapy, bispecific monoclonal antibodies, targeted therapy, and a promising antibody-drug conjugate.

CAR-T Cell Therapy:

In chimeric antigen receptor (CAR) T-cell therapy, T-cells from the patient’s blood are collected and engineered to exhibit unique structures called chimeric antigen receptors on their surface. They then are reinjected into the patient’s body, where the receptors help the T-cells identify the cancer cells and attack them. Three different treatments for leukaemia and lymphoma are available in the market, and hundreds of clinical trials are still underway. Some of the blood cancers this treatment targets include: follicular non-Hodgkin lymphoma, mantle cell lymphoma, diffuse large B-cell lymphoma, acute lymphoblastic leukaemia, multiple myeloma, and chronic lymphocytic leukaemia.

This treatment works well for most people with blood cancer and provides long remissions and even a complete cure in some cases, but many are still concerned about this treatment method. This method has a success rate of about 30-40 per cent for remission, with no additional treatment. Some side effects like neurotoxicity and severe cytokine release syndrome are observed in patients. To mitigate such side effects and possibly eliminate them, the best cancer doctors are working to improve this treatment method. 

Bispecific Monoclonal Antibodies:

To the patients who cannot receive treatment through CAR T-cell therapy, bispecific monoclonal antibodies provide a viable solution. These are artificially produced and can bind to two different types of antigen receptors. One such bispecific antibody, odronextamab, has shown positive results for non-Hodgkin lymphoma. The drug acts by stimulating the CD3 receptors of the patient’s cells to attack the cancer cells. Further research is underway to help the antibodies costimulate the CD28 receptors to enhance the T-cells even more. 

Every Lymphoma Cancer Doctor in Noida has shown interest in implementing this new treatment method, as we can readily adjust the drug dosage to suit the patient’s condition. 

Target Therapy for Leukemia:

This Leukemia cancer’s new treatment involves target therapy. This method has proven to be especially effective against acute myeloid leukaemia, which has a five-year survival rate of 28.7 per cent. This cancer continues when the affected blast cells remain perpetually undifferentiated and proliferate. Treatment method using KO-539, at Kura Oncology, San Diego, shows that the genetically targeted menin inhibitor can cure acute myeloid leukaemia. 

The inhibitor shuts off the expression of specific genes, which arrests the blast cells in a permanent undifferentiated state. Upon drug administration, the cells either undergo apoptosis (programmed cell death) or differentiate into mature cells which later die. The best Leukemia Cancer doctor in Noida guarantees that this method can give the patients complete remission when perfected. 

Antibody-Drug Conjugates for Lymphoma:

New treatments for lymphoma cancer involve targeted antibody-drug conjugates. These have surface receptors specific to monoclonal antibodies that link to toxic anticancer agents. 

The antibody part of the drug binds to ROR1 (a receptor found on many cancer cells). Once it enters the cell, the toxin is released, and the cell dies. This method is relatively new and requires further testing before it can be used for treating patients. 

Other treatments for broad-spectrum use include stem cell transplant, Chemotherapy, and Radiation therapy.

The type and stage of cancer have to be determined before it can be treated. Testes like polymerase chain reaction (PCR) and next-generation sequencing (NGS) allow us to predict the possibility of relapse in patients.

Dealing with cancer is difficult as one treatment method may not always work for everyone. That is why it is crucial to consult us, the Best Oncologist in Delhi who can explain the best treatment option for you or your loved ones.

Are you looking for a Blood Cancer doctor in Noida? Make sure to book a consultation with the Best Cancer Doctor in Delhi NCR , Dr Manish Singhal,  with us at Cancer Consult India.

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