Case History

  • The patient is a 33 years old female presented with dysfunctional uterine bleeding and diagnosed a polyp outside.
  • Pelvic pain prompted further investigation indicating pelvic masses.
  • Biopsy was done outside which was suggestive of poorly differentiated carcinoma.
  • She came to Delhi for further evaluation and management.
  • Subtyping failed , therefore repeat biopsy was done.
  • And then she was diagnosed with endometrial cancer.
  • PET CT Scan was done , which showed mass lesion in relation to uterus and large necrotic pelvic nodes and para-aortic nodes with lung lesion.
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  • In view of long wart between initial diagnosis and further subtyping of disease, 1 cycle chemo was given to forestall grave progression of disease beyond point of difficult return.
  • Post 1st cycle, there was drastic improvement in pain.
  • Again Biopsy was done, which confirmed Ca Endometrium High Grade WTI and PAX8 ER positive.
  • She was proposed chemotherapy but couldn’t afford it after few cycles.
  • Then she was proposed radiation but due to financial issues, she refused it.
  • Finally she agreed for Immunotherapy
  • Then she was put on Lenvatinib.
  • Because of unaffordable immunotherapy, the schedule was extended to once in 6 weeks.
  • Then it was further extended to once in 3 months.
  • Last schedule was given on -
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    Post 3 cycles, we recorded a very good response which was documented in the PET-CT scan.

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  • There were subsequent PET-CT scan done, for which comparisons are documented below.
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    PET-CT scan post 1 cycle of chemotherapy and 3 cycles of immunotherapy.

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    PET-CT scan post 5 cycles of chemotherapy and 4 cycles of immunotherapy

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    PET-CT scan after last cycle of Immunotherapy